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Well, since he still asks how to do it manually, he might just want to edit it temporarily.
@Topic:
You can edit the value of a register by doubleclicking on the register you want to edit in the top right corner of ODbg.
If you want to make that change "permanent" so that it is always done automatically without you having to start Olly, then you have to patch at the address and place a "mov register_to_edit, value", as the others already mentioned.
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