U need to find the routine that checks for running in a vm and patch it. If u don't know how to use a debugger, then u are screwed.
Here is a simple but powerful code to detect if running in VM:
Steps to find the code in debugger:
BreakPoint on MessageBoxW, trace back from there, note that League of Legends edits stack on the fly which means, return functions are wiped and restored in runtime, so tracing back is not as easy, but possible.