Running pc can effect your component lifespan, but its pretty much like 10 % or even less. Only stuff what can get ripped are coolers and hdd/ssd, other components are pretty much made for max usage. I personaly have home pc, i use it for storage, its running 24/7 for already 2 years, i am cleaning dust every month just to avoid overheating. In that 2 Years spent only 200 € for new HDD-s and 2 coolers