smbogdan, IsDebuggerPresent is a windows api, if your target programm is actually using it just do this:
press ctrl+g in olly and enter 'IsDebuggerPresent' now hit return, hit F2 to place a breakpoint, hit F9 to execute the programm, it should now break at your breakpoint, press F2 again to remove the breakpoint, now press ctrl+F9 to execute till return, modify the value of eax to 0 and press F9.
ofc you could also just patch the call to is debugger present and set eax to 0, or you could patch the actual check of the return value.
Lena's Reversing Tutorial for newbies does explain how to do this btw.